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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/491

Title: Nanoparticle-Sensitized Photodegradation of Bilirubin and Potential Therapeutic Application
Authors: Sarkar, Soumik
Makhal, Abhinandan
Baruah, Sunandan
Mahmood, Mohammad A
Dutta, Joydeep
Pal, Samir K
Issue Date: 2012
Publisher: J. Phys. Chem. C
Citation: S. Sarkar, A. Makhal, S. Baruah, M. Mahmood, J. Dutta and S. K. Pal, Nanoparticle-Sensitized Photodegradation of Bilirubin and Potential Therapeutic Application, J. Phys. Chem. C, 2012, 116, 9608.
Abstract: Bilirubin (BR) is a protective antioxidant; however, when its conjugation and excretion are impaired, as in neonatal and hereditary jaundice, BR accumulates and may cause severe neurotoxicity. Here, we report a novel mechanism for ZnO nanoparticle (NP)-sensitized BR degradation via defect-mediated nonradiative energy transfer pathway. Among different sizes and shapes, ZnO particles with diameter of 5 nm having very high concentration of defect states are found to be the most effective catalyst, which particularly follows a pseudofirst-order kinetics validating the Langmuir−Hinshelwood model of surface catalysis. The nontoxic wide band gap ZnO NPs essentially transmit defect-mediated visible optical radiation, which is not supposed to interfere with the conventional phototherapy process. Therefore, the recyclable ZnO nanocatalysts essentially invite an added advantage in potential therapeutic applications and/or in a flow-device that has been explored in the present study.
URI: http://hdl.handle.net/123456789/491
Appears in Collections:2012

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